Applications: WB, IHC, IHC-P, KD
Host: Rabbit Polyclonal
Host: Mouse Monoclonal
Host: Sheep Polyclonal
WB, ELISA, PA, PEP-ELISA, AP
Applications: WB, ELISA, PA, PAGE, AP
The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase 2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F, and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.
|Product By Gene ID
- S-phase kinase-associated protein 2
- F-box/LRR-repeat protein 1
- cyclin A/CDK2-associated protein p45
- F-box protein Skp2
- CDK2/cyclin A-associated protein p45
- Cyclin-A/CDK2-associated protein p45
- S-phase kinase-associated protein 2 (p45)
Research Areas for Skp2
Find related products by research area and learn more about each of the different research areas below.Cell Cycle and Replication
Bioinformatics Tool for Skp2
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Related Skp2 Blog Posts
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