Skp2 Products

Antibodies
Skp2 Antibody (712120)
Skp2 Antibody (712120)
MAB6817
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Skp2 Antibody
Skp2 Antibody
AF6817
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Skp2 Antibody
Skp2 Antibody
NBP2-49142
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Skp2 Overexpression Lysate (N ...
Skp2 Overexpression Lysate (Native)
NBL1-15995
Applications: WB
Skp2 Overexpression Lysate (D ...
Skp2 Overexpression Lysate (Denatu...
H00006502-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human Skp2 Protei ...
Recombinant Human Skp2 Protein
H00006502-P01
Species: Hu
Applications: WB, ELISA, PA, PEP-ELISA
Recombinant Human Skp2 Protei ...
Recombinant Human Skp2 Protein
H00006502-Q01
Species: Hu
Applications: WB, ELISA, PA
Skp2 Recombinant Protein Anti ...
Skp2 Recombinant Protein Antigen
NBP2-56192PEP
Species: Hu
Applications: AC
RNAi
Skp2 RNAi
Skp2 RNAi
H00006502-R01
Species: Hu
Applications: RNAi, RNAi SP
Skp2 RNAi
Skp2 RNAi
H00006502-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase 2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F, and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 6502
Alternate Names
  • p45skp2
  • S-phase kinase-associated protein 2
  • F-box/LRR-repeat protein 1
  • cyclin A/CDK2-associated protein p45
  • F-box protein Skp2
  • CDK2/cyclin A-associated protein p45
  • Cyclin-A/CDK2-associated protein p45
  • FBL1
  • FBXL1MGC1366
  • FLB1
  • S-phase kinase-associated protein 2 (p45)

Research Areas for Skp2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

Bioinformatics Tool for Skp2

Discover related pathways, diseases and genes to Skp2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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