Six5 Products

Six5 Antibody
Six5 Antibody
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Six5 Antibody
Six5 Antibody
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
Six5 Overexpression Lysate (N ...
Six5 Overexpression Lysate (Native)
Applications: WB
Six5 Recombinant Protein Anti ...
Six5 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
Six5 RNAi
Six5 RNAi
Species: Hu


Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.


Entrez Human
Uniprot Human
Product By Gene ID 147912
Alternate Names
  • BOR2
  • homeobox protein SIX5
  • DM locus-associated homeodomain protein
  • dystrophia myotonica-associated homeodomain protein
  • Sine oculis homeobox homolog 5
  • DMAHPsine oculis homeobox homolog 5 (Drosophila)
  • sine oculis homeobox (Drosophila) homolog 5
  • SIX homeobox 5

PTMs for Six5

Learn more about PTMs related to Six5.


Bioinformatics Tool for Six5

Discover related pathways, diseases and genes to Six5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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