SIAH2 Products

Description

The Drosophila SINA (seven in absentia) protein is an E3 ubiquitin ligase component of the RAS signal transduction pathway. The RAS signal pathway controls cell proliferation, differentiation, and survival, and regulation of this pathway is critical for normal development. In Drosophila, SINA serves as a downstream gatekeeper required for proper RAS signal transduction. Similarly to SINA in Drosophila, the human protein SIAH has also been shown to be required for oncogenic RAS signaling in cancer.

Bioinformatics

Entrez	140593 Rat 20439 Mouse 6478 Human
Uniprot	AAH13082 Human NM_005067 Human NP_005058.3 Human O43255 Human
Product By Gene ID	6478
Alternate Names	E3 ubiquitin-protein ligase SIAH2 EC 6.3.2 EC 6.3.2.- hSiah2 seven in absentia (Drosophila) homolog 2 seven in absentia homolog 2 (Drosophila) Seven in absentia homolog 2 Siah-2 siah-2

Research Areas for SIAH2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Chromatin Modifiers
Chromatin Research
Hypoxia
Immunology
Ubiquitin Proteasome Pathway
Wnt Signaling Pathway