Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rat Monoclonal
Species: Hu, Mu
Applications: WB, Flow, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Hu, Mu, RtApplications:
SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3, 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).
|Product By Gene ID
- EC 3.1.3
- Inositol polyphosphate-5-phosphatase of 145 kDa
- inositol polyphosphate-5-phosphatase, 145kDa
Bioinformatics Tool for SHIP
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Related SHIP Blog Posts
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|Getting SHIP-shape Over Tumour Suppression
PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymp... Read more.