RNF139 Products

Description

RNF139 is encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Bioinformatics

Entrez	11236 Human
Uniprot	NM_007218 Human NP_009149 Human NP_009149.2 Human Q8WU17 Human
Product By Gene ID	11236
Alternate Names	EC 6.3.2.- HRCA1 patched related protein translocated in renal cancer RCA1multiple membrane spanning receptor TRC8 ring finger protein 139MGC31961 Translocation in renal carcinoma on chromosome 8 protein TRC8E3 ubiquitin-protein ligase RNF139

Research Areas for RNF139

Find related products by research area and learn more about each of the different research areas below.

Zinc Finger