Rffl Products

Antibodies
Rffl Antibody
Rffl Antibody
NBP1-83426
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Rffl Antibody (3A4)
Rffl Antibody (3A4)
H00117584-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Rffl Antibody
Rffl Antibody
NBP2-20137
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
Lysates
Rffl Overexpression Lysate (N ...
Rffl Overexpression Lysate (Native)
NBP2-05804
Applications: WB
Proteins
Rffl Recombinant Protein
Rffl Recombinant Protein
H00117584-P01
Species: Hu
Applications: WB, ELISA, PA
Rffl Partial Recombinant Prot ...
Rffl Partial Recombinant Protein
H00117584-Q01
Species: Hu
Applications: WB, ELISA, PA
Rffl Recombinant Protein Anti ...
Rffl Recombinant Protein Antigen
NBP1-83427PEP
Species: Hu
Applications: AC
RNAi
Rffl RNAi
Rffl RNAi
H00117584-R01V
Species: Hu
Applications: WB, RNAi SP
Rffl RNAi
Rffl RNAi
H00117584-R01
Species: Hu
Rffl RNAi
Rffl RNAi
H00117584-R02
Species: Hu

Description

RFFL, also known as Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 117584
Alternate Names
  • EC 6.3.2
  • fring
  • RING finger protein 34-like
  • RING finger protein 189
  • Fring
  • RING finger and FYVE-like domain-containing protein 1
  • EC 6.3.2.-
  • CARP-2
  • E3 ubiquitin-protein ligase rififylin
  • FYVE-RING finger protein Sakura
  • RIFIFYLIN
  • Caspases-8 and -10-associated RING finger protein 2
  • Caspase regulator CARP2
  • RNF34LFRING
  • RNF189CARP2
  • rififylin
  • ring finger and FYVE-like domain containing 1

Diseases related to Rffl

Discover more about diseases related to Rffl.

Cardiac Death
Hypertensive Disease
Fibrosis
Cardiac Arrhythmia
Pulmonary Fibrosis
Sudden Cardiac Death

Pathways for Rffl

View related products by pathway and learn more about each of the pathways below.

Endocytic Recycling
Cell Migration
Fibroblast Migration

PTMs for Rffl

Learn more about PTMs related to Rffl.

Phosphorylation

Bioinformatics Tool for Rffl

Discover related pathways, diseases and genes to Rffl. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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