RFC1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

5981

Alternate Names

A1 140 kDa subunit A1 Activator 1 140 kDa subunit Activator 1 large subunit Activator 1 subunit 1 MGC51786 MHC binding factor, beta MHCBFB PO-GA RECC1 replication factor C (activator 1) 1 (145kD) replication factor C (activator 1) 1, 145kDa Replication factor C 140 kDa subunit Replication factor C large subunit replication factor C subunit 1 replication factor C1 RF-C 140 kDa subunit RFC RFC1 RFC140 RFC140DNA-binding protein PO-GA

Research Areas for RFC1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
DNA Repair