REM1 Products

Description

The Ras-encoded family of proteins bind GDP and GTP with high affinity. They possess a low level of intrinsic GTPase activity that increases more than 100-fold when interacting with cytosolic GTPase activating protein (GAP). Ras family members include H-Ras, K-Ras, N-Ras, M-Ras, R-Ras, ERas, Rheb, TC 21, RASL11B and Rad (Ras associated with diabetes) GTPase.Rad GTPase is a GTP-binding protein that is similar to Ras but has unique features. Unlike other small GTPases, Rad GTPase lacks typical pren-ylation motifs at its C terminus. The Rad GTPase enzyme binds calmodulin, inhibits vascular lesion formation, has low intrinsic GTPase activity and cannot be stimulated by any known GAP molecules. Rad GTPase is expressed in skeletal muscle, cardiac muscle and lung tissues and is overexpressed in the skeletal muscle tissue of individuals with type II diabetes.

Bioinformatics

Entrez	19700 Mouse 28954 Human
Uniprot	NP_054731 Human NP_054731.2 Human O75628 Human
Product By Gene ID	28954
Alternate Names	GESGD:REM GTPase GES GTPase-regulating endothelial cell sprouting GTP-binding protein REM 1 MGC48669 Rad and Gem-like GTP-binding protein 1 RAS (RAD and GEM)-like GTP-binding 1 RAS (RAD and GEM)-like GTP-binding REM

Research Areas for REM1

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Signal Transduction