RanBP2 Products

Description

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq]

Bioinformatics

Entrez	5903 Human
Uniprot	P49792 Human
Product By Gene ID	5903
Alternate Names	ANE1 E3 SUMO-protein ligase RanBP2 EC 5.2.1.8 Nuclear pore complex protein Nup358 nucleoporin 358 Nucleoporin Nup358 NUP358TRP2 p270 RAN binding protein 2 Ran-binding protein 2 RanBP2 transformation-related protein 2,358 kDa nucleoporin TRP1