Rad17 Products

Description

Signals originating from damaged DNA activate checkpoint pathways and target the mitotic apparatus via a number a distinct mechanisms. These checkpoints link damage to DNA with the components of the cell cycle through signal transduction systems. In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.(1).

Bioinformatics

Entrez	19356 Mouse 5884 Human
Uniprot	AAH32304 Human NM_002873 Human NM_133344 Human NP_002864.1 Human NP_579916 Human NP_579919 Human NP_579919.1 Human NP_579920 Human NP_579921 Human O75943 Human O75943-2 Human
Product By Gene ID	5884
Alternate Names	CCYC cell cycle checkpoint protein (RAD17) cell cycle checkpoint protein RAD17 FLJ41520 hRad17 HRAD17 R24L RAD1 (S. pombe) homolog RAD1 homolog RAD17 homolog (S. pombe) Rad17-like protein RAD17Sp RAD17SP RAD24 Rad24 RF-C activator 1 homolog RF-C/activator 1 homolog

Research Areas for Rad17

Find related products by research area and learn more about each of the different research areas below.

Cancer
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific