Rab5a Products

Antibodies
Rab5a Antibody
Rab5a Antibody
NB120-13253
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Rab5a Antibody
Rab5a Antibody
NBP1-20255
Species: Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Sheep Polyclonal
Rab5a Antibody
Rab5a Antibody
NBP1-58880
Species: Hu, Eq, Ma
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Rab5a Overexpression Lysate ( ...
Rab5a Overexpression Lysate (Native)
NBL1-15082
Applications: WB
Proteins
Rab5a Recombinant Protein
Rab5a Recombinant Protein
NBC1-18504
Species: Hu
Applications: PAGE
RNAi
Rab5a RNAi
Rab5a RNAi
H00005868-R01
Species: Hu

Description

Rab5 is a 24 kDa GTP-binding protein that regulates the fusion of plasma membrane -derived clathrin-coated vesicles with early endosomes, and homotypic fusion among early endosomes1. Localized to the cytoplasmic side of the plasma membrane, clathrin -coated vesicles and early endosomes, Rab5 appears to regulate vesicle fusion through a cycle of GDP/GTP e xchange and GTP hydrolysis. The different guanine nuc leotide binding states of Rab5 may affect its ability to associate or dissociate with membranes during endocytotic membrane traffic. The GTP-bound, or active, form of Rab5 associates with membrane s and regulates vesicle docking and fusion. Studies using a Rab5 mutant that hydrolyzed xanthosine 5 -triphosphate (XTP) indicated that nucleotide hydrolysis occurs even in the absence of membrane fusion. GTP hydrolysis by Rab5 may determine the frequency of membrane docking and fusion events.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5868
Alternate Names
  • ras-related protein Rab-5A
  • RAB5RAS-associated protein RAB5A
  • RAB5A, member RAS oncogene family

Research Areas for Rab5a

Find related products by research area and learn more about each of the different research areas below.

Endosome Markers
Signal Transduction

Bioinformatics Tool for Rab5a

Discover related pathways, diseases and genes to Rab5a. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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