PTP sigma/PTPRS Products

Description

The protein encoded by the PTPRS gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. (provided by RefSeq)

Bioinformatics

Entrez	5802 Human
Uniprot	AAH29496 Human NM_002850 Human NM_130853 Human NM_130854 Human NM_130855 Human Q13332 (Human) Human Q13332 Human
Product By Gene ID	5802
Alternate Names	EC 3.1.3.48 protein tyrosine phosphatase PTPsigma protein tyrosine phosphatase, receptor type, S protein tyrosine phosphatase, receptor type, sigma PTPSIGMA receptor-type tyrosine-protein phosphatase S Receptor-type tyrosine-protein phosphatase sigma R-PTP-S R-PTP-sigma