PTGER2 Products

Antibodies
PTGER2 Antibody (607077)
PTGER2 Antibody (607077)
MAB6656
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
PTGER2 Antibody
PTGER2 Antibody
NBP1-02321
Species: Hu, Mu, Po, Bt, Bv, Canine, Primate, Rat, Monkey
Applications: ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
PTGER2 Antibody
PTGER2 Antibody
NBP1-00809
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
PTGER2 Overexpression Lysate ...
PTGER2 Overexpression Lysate (Dena...
H00005732-T01
Species: Hu
Applications: WB
Proteins
PTGER2 Recombinant Protein
PTGER2 Recombinant Protein
H00005732-P01
Species: Hu
Applications: WB, ELISA, PA
PTGER2 Recombinant Protein
PTGER2 Recombinant Protein
H00005732-G01
Species: Hu
RNAi
PTGER2 RNAi
PTGER2 RNAi
H00005732-R02
Species: Hu

Description

Prostaglandin E2, a member of the autacoid family of lipid mediators, is a major renal cyclooxygenase product of arachidonic acid metabolism.Prostaglandin E2 binds to four G protein-coupled E-prostanoid receptors,designated EP1, EP2, EP3 and EP4. The expression and function of the prostaglandin E2 receptors have been highly characterized in kidney. EP1,which is predominantly expressed in the collecting duct, couples to Gq proteins to inhibit sodium absorption and increase in intracellular calcium, which act as second messengers. EP2 is coupled to Gs proteins, which stimulate adenylyl cyclase. EP2 has the lowest expression in kidney, but EP2 knockout mice exhibit salt-sensitive hypertension, which suggests a role for EP2 in salt excretion. EP3 is expressed in renal vessels, thick ascending limb and collecting duct. EP3 has at least 6 alternative splice variants that couple to Gi proteins to inhibit cAMP, which subsequently inhibit sodium and water transport. In uterus, EP3 induces the contraction of uterine smooth muscles.EP4 is expressed in glomerulus and collecting duct. It couples to Gs proteins,which stimulate adenylyl cyclase and regulate glomerular tone and renal renin release.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Product By Gene ID 5732
Alternate Names
  • PGE receptor EP2 subtype
  • prostaglandin E2 receptor EP2 subtype
  • Prostanoid EP2 receptor
  • prostaglandin E receptor 2 (subtype EP2), 53kD
  • EP2
  • PGE2 receptor EP2 subtype
  • prostaglandin E receptor 2 (subtype EP2), 53kDa

Research Areas for PTGER2

Find related products by research area and learn more about each of the different research areas below.

Cancer
GPCR
Signal Transduction

Bioinformatics Tool for PTGER2

Discover related pathways, diseases and genes to PTGER2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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