PSMD8 Products

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq]

Bioinformatics

Entrez	5714 Human
Uniprot	AAH01164 Human NP_002803 Human P48556 Human
Product By Gene ID	5714
Alternate Names	26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit p31 HIP6,26S proteasome regulatory subunit S14 HYPF MGC1660 Nin1p p3126S proteasome regulatory subunit RPN12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Rpn12 S14

Research Areas for PSMD8

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication