Proteasome 19S 10B Products

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multi-subunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome and Liddle syndrome.

Bioinformatics

Entrez	5708 Human
Uniprot	AAH02368 Human AAH07897 Human AAH07897.1 Human NM_002808 Human NP_002799 Human NP_002799. Human Q13200 Human
Product By Gene ID	5708
Alternate Names	26S proteasome regulatory subunit RPN1 26S proteasome regulatory subunit S2 MGC14274,55.11 protein P97 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Protein 55.11 Rpn1 S226S proteasome non-ATPase regulatory subunit 2 TNFR-associated protein 2 TRAP226S proteasome subunit p97 tumor necrosis factor receptor-associated protein 2 Tumor necrosis factor type 1 receptor-associated protein 2

Research Areas for Proteasome 19S 10B

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Neuroscience
Ubiquitin Proteasome Pathway