Proteasome 19S 10B Products

Antibodies
Proteasome 19S 10B Antibody ( ...
Proteasome 19S 10B Antibody (1G6)
Species: Hu, Mu, Rt, Ca, Mk, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Proteasome 19S 10B Antibody
Proteasome 19S 10B Antibody
NB100-1483
Species: Hu, Mu
Applications: WB, ICC/IF, LA, PEP-ELISA
Host: Goat Polyclonal
Proteasome 19S 10B Antibody
Proteasome 19S 10B Antibody
NBP1-92291
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Proteasome 19S 10B Overexpres ...
Proteasome 19S 10B Overexpression ...
H00005708-T01
Species: Hu
Applications: WB
Proteasome 19S 10B Overexpres ...
Proteasome 19S 10B Overexpression ...
NBL1-14900
Applications: WB
Proteins
Proteasome 19S 10B Recombinan ...
Proteasome 19S 10B Recombinant Pro...
H00005708-P01
Species: Hu
Applications: WB, ELISA, PA
Proteasome 19S 10B Recombinan ...
Proteasome 19S 10B Recombinant Pro...
NBP1-92291PEP
Species: Hu
Applications: AC
RNAi
Proteasome 19S 10B RNAi
Proteasome 19S 10B RNAi
H00005708-R01
Species: Hu

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multi-subunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome and Liddle syndrome.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 5708
Alternate Names
  • 26S proteasome regulatory subunit RPN1
  • tumor necrosis factor receptor-associated protein 2
  • Tumor necrosis factor type 1 receptor-associated protein 2
  • TNFR-associated protein 2
  • Protein 55.11
  • Rpn1
  • P97
  • MGC14274,55.11 protein
  • S226S proteasome non-ATPase regulatory subunit 2
  • TRAP226S proteasome subunit p97
  • 26S proteasome regulatory subunit S2
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

Pathways for Proteasome 19S 10B

View related products by pathway and learn more about each of the pathways below.

Proteolysis
Cell Death
Cell Adhesion
Mitosis
Metaphase
Muscle Atrophy
Regeneration
Coagulation
Translation
Fibrinolysis
Protein Folding
Rna Interference
Apoptotic Process

Research Areas for Proteasome 19S 10B

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Neuroscience
Ubiquitin Proteasome Pathway

PTMs for Proteasome 19S 10B

Learn more about PTMs related to Proteasome 19S 10B.

Cleavage
Phosphorylation
Ubiquitination

Bioinformatics Tool for Proteasome 19S 10B

Discover related pathways, diseases and genes to Proteasome 19S 10B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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