PRKAG3 Products

Description

PRKAG3 is encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq]

Bioinformatics

Entrez	53632 Human
Uniprot	NM_017431 Human NP_059127 Human NP_059127.2 Human
Product By Gene ID	53632
Alternate Names	AMPK gamma-3 chain AMPK subunit gamma-3 AMPK gamma3 AMPKG3,5'-AMP-activated protein kinase, gamma-3 subunit 5'-AMP-activated protein kinase subunit gamma-3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit

Diseases related to PRKAG3

Discover more about diseases related to PRKAG3.

Refractory Neutropenia
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Insulin Resistance
Storage Disease
Hypoxia
Glycogen Storage Disease
Wolff-parkinson-white Syndrome
Malignant Neoplasms
Dysequilibrium Syndrome
Hypertrophy
Patient Dependence On
Insulin Sensitivity
Metabolic Diseases
Obesity
Malignant Neoplasm Of Breast
Glycogen Storage Disease Type Ii
Swine Diseases
Cardiomyopathy, Hypertrophic, Familial

Pathways for PRKAG3

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Energy Homeostasis
Lipid Oxidation
Transport
Glucose Transport
Proteolysis
Pathogenesis
Glycolysis
Regulation Of Energy Homeostasis
Circadian Rhythm
Insulin Secretion
Camp-mediated Signaling
Regulation Of Gene Expression
Oocyte Maturation
Regulation Of Glucose Transport
Glucose Homeostasis
Methylation
Swimming
Translation
Secretion

Research Areas for PRKAG3

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Signal Transduction

PTMs for PRKAG3

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Phosphorylation
Oxidation
Deacetylation
Methylation

Bioinformatics Tool for PRKAG3

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