PRKAG3 Products

Description

PRKAG3 is encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq]

Bioinformatics

Entrez	53632 Human
Uniprot	NM_017431 Human NP_059127 Human NP_059127.2 Human
Product By Gene ID	53632
Alternate Names	5'-AMP-activated protein kinase subunit gamma-3 AMPK gamma-3 chain AMPK gamma3 AMPK subunit gamma-3 AMPKG3,5'-AMP-activated protein kinase, gamma-3 subunit protein kinase, AMP-activated, gamma 3 non-catalytic subunit

Research Areas for PRKAG3

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Signal Transduction