PRELP Products

Description

PRELP is encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]

Bioinformatics

Entrez	5549 Human
Uniprot	NM_002725 Human NM_201348 Human NP_002716 Human NP_002716.1 Human
Product By Gene ID	5549
Alternate Names	55 kDa leucine-rich repeat protein of articular cartilage MST161 MSTP161 prolargin proteoglycan prolargin proline arginine-rich end leucine-rich repeat protein proline/arginine-rich end leucine-rich repeat protein Proline-arginine-rich end leucine-rich repeat protein SLRR2AMGC45323