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HAF016). A specific band was detected for PRELP at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
6447-PR) inhibits TRANCE-induced osteoclast differentiation in the RAW 264.7 mouse monocyte/macrophage cell line in a dose-dependent manner (orange line), as measured by the Tartrate-resistant acid phosphatase activity assay. Under these conditions, TRANCE-induced osteoclast differentiation inhibited by Recombinant Human PRELP (5 µg/ml) is neutralized (green line) by increasing concentrations of Mouse Anti-Human PRELP Monoclonal Antibody (Catalog # MAB64471) in the presence of 5 ng/mL Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TEC) and 20 ng/mL Recombinant Mouse M-CSF (Catalog # 416-ML). The ND50 is typically 0.25-1.25 µg/mL." class="big_lightbox" target="_blank">
PRELP is encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
![Western Blot PRELP Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PRELP_AF6447_Western_Blot_11110.jpg)
![Immunocytochemistry PRELP Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/PRELP_AF6447_Immunocytochemistry_12159.jpg)
![Immunohistochemistry PRELP Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af6447_human-prelp-affinity-purified-polyclonal-ab-immunohistochemistry-1212202592691.jpg)
![Immunohistochemistry PRELP Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af6447_human-prelp-affinity-purified-polyclonal-ab-immunohistochemistry-121220259245216.jpg)
