PPP3CC Products

Description

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM]

Bioinformatics

Entrez	5533 Human
Uniprot	NM_005605 Human NP_005596 Human NP_005596.2 Human P48454 Human
Product By Gene ID	5533
Alternate Names	Calcineurin, testis-specific catalytic subunit Calmodulin-dependent calcineurin A subunit gamma isoform CALNA3CAM-PRP catalytic subunit CNA3 EC 3.1.3.16 PP2Bgamma protein phosphatase 2B, catalytic subunit, gamma isoform protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform(calcineurin A gamma) protein phosphatase 3, catalytic subunit, gamma isozyme serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform