PPM1E Products

Description

The protein encoded by the PPM1E gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42). (provided by RefSeq)

Bioinformatics

Entrez	22843 Human
Uniprot	Q8WY54 Human
Product By Gene ID	22843
Alternate Names	ca(2+)/calmodulin-dependent protein kinase phosphatase N caMKN CAMKN CaMKP-N caMKP-nucleus DKFZp781F1422 KIAA1072 nuclear calmodulin-dependent protein kinase phosphatase partner of PIX 1 partner of PIXA partner of PIX-alpha POPX1 PP2CH protein phosphatase 1E (PP2C domain containing) protein phosphatase 1E protein phosphatase, Mg2+/Mn2+ dependent, 1E

Research Areas for PPM1E

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Protein Phosphatase