PP1 alpha/PPP1A Products

Description

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favouring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).

Bioinformatics

Entrez	19045 Mouse 24668 Rat 5499 Human
Uniprot	AAH08010.1 Human NM_002708 Human NP_001008709 Human NP_002699 Human P62136 Human Q07161 Human
Product By Gene ID	5499
Alternate Names	EC 3.1.3.16 PP1alpha PP-1AMGC15877 PPP1AMGC1674 protein phosphatase 1, catalytic subunit, alpha isoform protein phosphatase 1, catalytic subunit, alpha isozyme serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Research Areas for PP1 alpha/PPP1A

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Phosphatase