POLR3A Products

Description

RNA polymerase III (Pol III) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA. POLR3A (polymerase (RNA) III (DNA directed) polypeptide A), also known as RPC1 or RPC155, is a 1,390 amino acid protein that localizes to the nucleus and belongs to the RNA polymerase beta chain family. Existing as the largest and catalytic core component of Pol III, POLR3A functions as a DNA-dependent RNA polymerase that catalyzes the conversion of a nucleoside triphosphate into a diphosphate, thereby transcribing DNA into RNA. The gene encoding POLR3A maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Bioinformatics

Entrez	11128 Human 540308 Bovine 66368 Mouse
Uniprot	NP_008986 Human O14802 Human
Product By Gene ID	11128
Alternate Names	DNA-directed RNA polymerase III largest subunit DNA-directed RNA polymerase III subunit A DNA-directed RNA polymerase III subunit RPC1 EC 2.7.7.6 hRPC155 POL3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa RNA polymerase III 155 kDa subunit RNA polymerase III subunit C160 RNA polymerase III subunit RPC155-D RPC1 RPC155RNA polymerase III subunit C1