PLOD1 Products

Description

Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq]

Bioinformatics

Entrez	5351 Human
Uniprot	NP_000293 Human NP_000293.2 Human
Product By Gene ID	5351
Alternate Names	2-oxoglutarate 5-dioxygenase 1 EC 1.14.11.4 Ehlers-Danlos syndrome type VI) FLJ42041 LH1 LLH lysine hydroxylase Lysyl hydroxylase 1 PLODLH procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 procollagen-lysine procollagen-lysine, 2-oxoglutarate 5-dioxygenase