PLC-beta 3 Products

Antibodies
PLC-beta 3 Antibody
PLC-beta 3 Antibody
NBP2-32026
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PLC-beta 3 Antibody
PLC-beta 3 Antibody
NBP2-31974
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PLC-beta 3 Antibody
PLC-beta 3 Antibody
AF4716
Species: Hu
Applications: WB
Host: Sheep Polyclonal
Proteins
PLC-beta 3 Recombinant Protei ...
PLC-beta 3 Recombinant Protein Ant...
NBP2-32026PEP
Species: Hu
Applications: AC
PLC-beta 3 Recombinant Protei ...
PLC-beta 3 Recombinant Protein Ant...
NBP2-31974PEP
Species: Hu
Applications: AC
RNAi
PLC-beta 3 RNAi
PLC-beta 3 RNAi
H00005331-R01
Species: Hu

Description

Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1 and PLC delta2) with molecular weights ranging from 85 to 150 kDa. The gamma-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two gamma-type enzymes, but not the beta and delta isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC beta1, PLC beta2 and PLC beta3 is mediated by the alpha subunits of the Gq class of heterotrimeric G proteins and by certain betagamma G protein subunits. The regulatory mechanisms for PLC delta1 and PLC delta2 are as yet not resolved.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 5331
Alternate Names
  • Phospholipase C-beta-3
  • EC 3.1.4.11
  • PLC beta 3
  • PLC-beta-3
  • FLJ37084
  • Phosphoinositide phospholipase C-beta-3
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
  • phospholipase C, beta 3 (phosphatidylinositol-specific)

Research Areas for PLC-beta 3

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Phospho-Specific

PTMs for PLC-beta 3

Learn more about PTMs related to PLC-beta 3.

Phosphorylation
Dephosphorylation
Cleavage

Bioinformatics Tool for PLC-beta 3

Discover related pathways, diseases and genes to PLC-beta 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.