Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
PTMs for Plakophilin 2
Learn more about PTMs related to Plakophilin 2.Phosphorylation
Bioinformatics Tool for Plakophilin 2
Discover related pathways, diseases and genes to Plakophilin 2. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.