Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
Bioinformatics
| Entrez |
Rat
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
5318 |
| Alternate Names |
- ARVD9
- MGC177501
- plakophilin 2
- plakophilin-2
|
