PKLR Products

Description

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also known as type R. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	5313
Alternate Names	EC 2.7.1.40 PK1 PK1PKRL PKL PKLR PKR Pyruvate Kinase 1 pyruvate kinase isozyme R/L pyruvate kinase isozymes R/L pyruvate kinase type L pyruvate kinase, liver and blood cell pyruvate kinase, liver and RBC Red cell/liver pyruvate kinase RPK R-type/L-type pyruvate kinase

Research Areas for PKLR

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism