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The protein encoded by the Pyruvate Kinase gene is a pyruvate kinase that catalyzes the transphosphorylation of phosphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)
![Western Blot PKLR Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/PKLR_AF8519_Western_Blot_16592.jpg)
![Simple Western PKLR Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af8519_human-mouse-rat-pklr-affinity-purified-pab-simple-western-1342022154119.jpg)
