Applications: WB, Simple Western, CyTOF-ready, Flow
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Simple Western
Host: Sheep Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, ELISA, PA, PAGE, AP
Applications: RNAi, RNAi SP
Members of the protein kinase C (PKC) family play a key regulatory role in variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (alpha, betaI, betaII and gamma) and novel (n) PKC isoforms (delta, episilon, zeta, eta and theta). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and episilon are independent of Ca++. On the other hand, nPKC and episilon, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.
Bioinformatics Tool for PKC theta
Discover related pathways, diseases and genes to PKC theta. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.