PIK3R5 Products

Description

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85alpha and p85beta), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110alpha and p110beta interact with p85alpha, and p110alpha has also been shown to interact with p85beta in vitro. p110delta expression is restricted to white blood cells. It has been shown to bind p85alpha and beta, but it apparently does not phosphorylate these subunits. p110delta seems to have the capacity to autophosphorylate. p110gamma does not interact with the p85 subunits. It has been shown to be activated by alpha and betagamma heterotrimeric G proteins.

Bioinformatics

Entrez	23533 Human 320207 Mouse
Uniprot	AAH28212.1 Human NM_014308 Human NP_001136105 Human NP_055123 Human Q8WYR1 Human
Product By Gene ID	23533
Alternate Names	F730038I15Rik FOAP-2 p101 P101-PI3K p101-PI3K Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit phosphoinositide-3-kinase, regulatory subunit 5 phosphoinositide-3-kinase, regulatory subunit, polypeptide p101 PI3-kinase p101 subunit PI3-kinase regulatory subunit 5 PtdIns-3-kinase regulatory subunit regulatory subunit 5, p101