PHF7 Products

Description

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. In the testis, this gene is expressed in Sertoli cells but not germ cells. However, this gene is not expressed in a patient who exhibited spermatogenic arrest at the spermatocyte stage. Spermatogenic arrest is an interruption of germ cell differentiation that may result in oligospermia or azoospermia. The proteins encoded by this gene contain plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. Thus this protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Two protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]

Bioinformatics

Uniprot	NM_016483 Human Q9BWX1 Human NP_057567 Human NP_057567.3 Human
Product By Gene ID	51533
Alternate Names	Testis development protein NYD-SP6 MGC26088 NYD-SP6 HSPC045 HSPC226 DKFZp434L1850 PHD finger protein 7

Diseases related to PHF7

Discover more about diseases related to PHF7.

Spermatogenesis Arrest
Infertility
Cystic Fibrosis
Fibrosis
Male Infertility
Choriocarcinoma
Congenital Absence Of Germinal Epithelium Of Testes

Pathways for PHF7

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Localization
Spermatogenesis
Fertilization
Stem Cell Maintenance
Sex Determination
Acrosome Reaction
Cell Cycle
Sperm Capacitation
Meiotic Cell Cycle
Histone Acetylation
S Phase
Male Sex Determination
Secretion

PTMs for PHF7

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Acetylation

Bioinformatics Tool for PHF7

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