PFKFB2 Products

Antibodies
PFKFB2 Antibody
PFKFB2 Antibody
NBP2-33584
Species: Hu, Mouse, Rat
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PFKFB2 Antibody
PFKFB2 Antibody
NBP2-32194
Species: Hu, Mu, Primate, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
PFKFB2 Antibody
PFKFB2 Antibody
NB100-92206
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
PFKFB2 Antibody Pair
PFKFB2 Antibody Pair
H00005208-PW1
Species: Hu
Applications: WB, IP
Lysates
PFKFB2 Overexpression Lysate ...
PFKFB2 Overexpression Lysate (Dena...
H00005208-T01
Species: Hu
Applications: WB
PFKFB2 Overexpression Lysate ...
PFKFB2 Overexpression Lysate (Native)
NBL1-14311
Applications: WB
Proteins
PFKFB2 Partial Recombinant Pr ...
PFKFB2 Partial Recombinant Protein
H00005208-Q01
Species: Hu
Applications: WB, ELISA, PA
PFKFB2 Recombinant Protein
PFKFB2 Recombinant Protein
H00005208-P01
Species: Hu
Applications: WB, ELISA, PA
PFKFB2 Recombinant Protein An ...
PFKFB2 Recombinant Protein Antigen
NBP2-33584PEP
Species: Hu
Applications: AC
RNAi
PFKFB2 RNAi
PFKFB2 RNAi
H00005208-R05
Species: Hu
Applications: RNAi, RNAi SP
PFKFB2 RNAi
PFKFB2 RNAi
H00005208-R06
Species: Hu
Applications: RNAi, RNAi SP

Description

Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Human PFK-1 is tetrameric and isoenzymes include, PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B) and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose 2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate and contains fructose 2,6-biphosphatase activity that catalyzes the degradation of fructose 2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 5208
Alternate Names
  • DKFZp781D2217
  • PFKFB, cardiac
  • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
  • fructose-2,6-bisphosphatase, cardiac isozyme
  • PFK/FBPase 2
  • PFK-2/FBPase-2
  • 6PF-2-K/Fru-2,6-P2ase 2
  • MGC138310
  • MGC138308,6PF-2-K/Fru-2,6-P2ase heart-type isozyme
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

PTMs for PFKFB2

Learn more about PTMs related to PFKFB2.

Phosphorylation
Methylation

Bioinformatics Tool for PFKFB2

Discover related pathways, diseases and genes to PFKFB2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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