PF1 Products

Description

PHD factor 1 (PF1) was identified as a protein that interacts with mSin3A-histone deacetylase corepressor, a multiprotein complex that mediates transcriptional repression. PF1 is a plant homeodomain zinc finger protein that also bears a forkhead-associated (FHA) domain. PF1 appears to facilitate the recruitment of the mSin3A complex to DNA for transcriptional repression. It has also been shown to interact with the histone deacetylase containing corepressor transducin-like enhancer of split (TLE) and may play a role in bridging the mSin3A and TLE transcriptional networks. Alternate names for PF1 include PHF12, PHD finger protein 12, and KIAA1523.

Bioinformatics

Uniprot	NP_001028733 Human NP_001028733.1 Human Q96QT6 Human
Product By Gene ID	57649
Alternate Names	Pf1 PHD factor 1 PHD zinc finger transcription factor PF1 KIAA1523MGC131914 FLJ34122 PHD finger protein 12

Diseases related to PF1

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Neoplasms
Melanoma
Hypoxia
Sudden Infant Death Syndrome
Neoplasm Invasiveness
Malignant Tumor Of Cervix
Carcinoma
Malignant Neoplasms
Malignant Neoplasm Of Nasopharynx
Mammary Neoplasms
Anoxia

Pathways for PF1

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Senescence
Histone Deacetylation
Cell Cycle
Cellular Senescence
Histone Acetylation
Cell Growth
Localization

PTMs for PF1

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Acetylation

Bioinformatics Tool for PF1

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