Peripherin Products

Description

Peripherin is a type III intermediate filament protein that is expressed in peripheral and some central nervous system (CNS) neurons. Peripherin activation is known to be induced by leukemia inhibitory factor (LIF). LIF activates Peripherin by inducing members of STAT transcription factor family to bind to a specific promoter element in the Peripherin gene. IL-6 is also known to induce Peripherin expression. Although it is not essential for neurite formation, peripherin is necessary for cellular intermediate filament network formation. Peripherin, unlike most intermediate filament proteins, has been reported to be modified by tyrosine phosphorylation.

Bioinformatics

Entrez	5630 Human 24688 Rat
Product By Gene ID	5630
Alternate Names	neurofilament 4 (57kD) Neurofilament 4 peripherin PRPH1NEF4

Research Areas for Peripherin

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cellular Markers
Neuronal Cell Markers
Neuroscience
Signal Transduction

Related Peripherin Blog Posts

Check out the latest blog posts on Peripherin.

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents Jamshed Arslan, Pharm D, PhD The dorsal root ganglia (DRG) are a collection of cell bodies of sensory nerves carrying sensory information – including nociception, mechanoreception and proprioception – from periphera...    Read more.

A Look at Peripherin: The Unknown Filament The exact function of Peripherin, or Neurofilament 4, is unknown however it has been suggested to play a role in axon formation and determining and maintaining the shape of nerve cells. Peripherin is a 470 amino acid Class-III neuronal intermediate fi...    Read more.

Read more Peripherin related blogs.