PEG10 Products

Description

paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frame shifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Bioinformatics

Uniprot	NM_001040152 Human NM_015068 Human NP_001035242.1 Human Q86TG7 Human
Product By Gene ID	23089
Alternate Names	embryonal carcinoma differentiation regulated Embryonal carcinoma differentiation-regulated protein HB-1 KIAA1051EDR Mammalian retrotransposon-derived protein 2 MAR2 Mar2 Mart2 MART2 MEF3 like 1 MEF3L MEF3L1 Myelin expression factor 3-like protein 1 paternally expressed 10 Paternally expressed gene 10 protein retrotransposon gag domain containing 3 Retrotransposon gag domain-containing protein 3 Retrotransposon-derived gag-like polyprotein retrotransposon-derived protein PEG10 RGAG3MEF3-like protein 1 Ty3/Gypsy-like protein