PDE6D Products

Antibodies
PDE6D Antibody
PDE6D Antibody
NBP1-32730
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PDE6D Antibody
PDE6D Antibody
NBP1-86275
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
PDE6D Antibody (5C7)
PDE6D Antibody (5C7)
H00005147-M06
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
PDE6D Overexpression Lysate ( ...
PDE6D Overexpression Lysate (Native)
NBL1-14228
Applications: WB
Proteins
PDE6D Recombinant Protein
PDE6D Recombinant Protein
NBP1-44480
Species: Hu
Applications: PAGE
PDE6D Recombinant Protein
PDE6D Recombinant Protein
H00005147-P01
Species: Hu
Applications: WB, ELISA, PA
PDE6D Recombinant Protein Ant ...
PDE6D Recombinant Protein Antigen
NBP1-86275PEP
Species: Hu
Applications: AC
RNAi
PDE6D RNAi
PDE6D RNAi
H00005147-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

PDE6D is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways, such as insulin secretion, platelet aggregation, smooth muscle relaxation, olfaction, and vision. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. While mammalian PDEs are divided into major families based on their substrate specificities, kinetic properties, allosteric regulators, inhibitor sensitivities, and amino acid sequences, each family and even members within a family display distinct tissue, cell, and subcellular expression patters. This suggests that individual PDE family members are involved in discrete signal transduction pathways. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha® (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha®/alpha® homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 5147
Alternate Names
  • retinal rod rhodopsin-sensitive cGMP 3'-5'-cyclic phosphodiesterase subunitdelta
  • GMP-PDE delta
  • PDED
  • Protein p17
  • phosphodiesterase 6D, cGMP-specific, rod, delta

Pathways for PDE6D

View related products by pathway and learn more about each of the pathways below.

Transport
Phototransduction
Localization
Lipid Binding
Prenylation
Protein Transport

Research Areas for PDE6D

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction
Vision

PTMs for PDE6D

Learn more about PTMs related to PDE6D.

Prenylation
Farnesylation
Phosphorylation
Geranylgeranylation
Ribosylation

Bioinformatics Tool for PDE6D

Discover related pathways, diseases and genes to PDE6D. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.