PCPTP1 Products

Description

PCPTP1, also known as Receptor-type tyrosine-protein phosphatase R, has 4 isoforms, a 657 amino acid isoform that is 74 kDa, a 412 amino acid isoform t5hat is 47 k Da, a 451 amino acid isoform that is 51 kDa, and a 545 amino acid isoform that is 61 kDa, expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate, sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. The protein is being studied for its involvement in colorectal cancer, episodic ataxia, ataxia, leukemia, prostatitis, and neuronitis. This protein has also been shown to involve MAPK1, MAPK14, MAPK3, MAPK7, and CDH2 in MAPK signaling pathway, EGFR1 Signaling Pathway, Signal transduction Erk Interactions- Inhibition of Erky, and Epithelial Adherens Junctions pathways.

Bioinformatics

Uniprot	NM_130846 Human NP_002840 Human Q15256 Human Q2TAJ3 Human Q7Z2V8 Human
Product By Gene ID	5801
Alternate Names	Ch-1 PTPase ch-1PTPase Ch-1PTPase DKFZp781C1038 EC 3.1.3.48 ECPTP EC-PTP FLJ34328 MGC131968 MGC148170 NC-PTPCOM1 PCPTP1 protein tyrosine phosphatase Cr1PTPase protein tyrosine phosphatase, receptor type, R protein-tyrosine phosphatase NC-PTPCOM1 Protein-tyrosine phosphatase PCPTP1 PTPBR7 PTPRQ PTP-SL receptor-type tyrosine-protein phosphatase R R-PTP-R

Research Areas for PCPTP1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience