Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Sheep Polyclonal
Species: Hu, Rt
Applications: WB
Host: Rabbit Monoclonal
Description
pan RhO/RAC/CDC42 is encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Bioinformatics
| Product By Gene ID |
387 |
| Alternate Names |
- h12
- oncogene RHO H12
- ras homolog gene family, member A
- Rho cDNA clone 12
- RHO12
- Rho12
- RhoA
- RHOH12ARH12ARHAAplysia ras-related homolog 12
- small GTP binding protein RhoA
- transforming protein RhoA
|
