pan RhO/RAC/CDC42 Products

Description

pan RhO/RAC/CDC42 is encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Bioinformatics

Product By Gene ID	387
Alternate Names	Rho12 transforming protein RhoA h12 small GTP binding protein RhoA RHO12 oncogene RHO H12 Rho cDNA clone 12 RHOH12ARH12ARHAAplysia ras-related homolog 12 RhoA ras homolog gene family, member A

Diseases related to pan RhO/RAC/CDC42

Discover more about diseases related to pan RhO/RAC/CDC42.

Tissue Adhesions
Malignant Neoplasms
Neoplasms
Cell Invasion
Neoplasm Metastasis
Carcinoma
Neoplasm Invasiveness
Hypertensive Disease
Inflammation
Cell Transformation, Neoplastic
Pathologic Vasoconstriction
Nervousness
Tumor Angiogenesis
Malignant Neoplasm Of Breast
Hypertrophy
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Fibrosis
Atherosclerosis
Cardiovascular Diseases

Pathways for pan RhO/RAC/CDC42

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Cell Migration
Localization
Cell Proliferation
Cell Adhesion
Cell Motility
Cell Cycle
Secretion
Pathogenesis
Cell Growth
Cytokinesis
Sensitization
Angiogenesis
Regeneration
Rna Interference
Muscle Contraction
Smooth Muscle Contraction
Vasoconstriction
Chemotaxis
Transport
Cell Death

Research Areas for pan RhO/RAC/CDC42

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mTOR Pathway
Signal Transduction
Wnt Signaling Pathway

PTMs for pan RhO/RAC/CDC42

Learn more about PTMs related to pan RhO/RAC/CDC42.

Phosphorylation
Ribosylation
Prenylation
Cleavage
Geranylgeranylation
Dephosphorylation
Farnesylation
Methylation
Ubiquitination
Deamidation
Myristoylation
Acetylation
Glycosylation
Amidation
Reduction
Nitration
Demethylation
Oxidation
Palmitoylation
Biotinylation

Bioinformatics Tool for pan RhO/RAC/CDC42

Discover related pathways, diseases and genes to pan RhO/RAC/CDC42. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.