PACRG Products

Description

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	135138 Human
Uniprot	NP_001073847.1 Human
Product By Gene ID	135138
Alternate Names	FLJ32724 Glup HAK005771 Molecular chaperone/chaperonin-binding protein PARK2 coregulated gene protein PARK2 co-regulated PARK2CRG parkin coregulated gene protein parkin co-regulated gene protein RP3-495O10.2

Research Areas for PACRG

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Neurodegeneration
Neuroscience