PA28 Activator beta Subunit/PSME2 Products

Antibodies
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
H00005721-M02
Species: Hu
Applications: WB, ELISA, IHC, IHC-P, IP
Host: Mouse Monoclonal
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
NB120-2940
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
H00005721-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Antibody Pairs
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
H00005721-PW1
Species: Hu
Applications: WB, IP
Lysates
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
H00005721-T01
Species: Hu
Applications: WB
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
NBL1-14908
Applications: WB
Proteins
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
NBP1-72527
Species: Hu
Applications: PAGE
RNAi
PA28 Activator beta Subunit/P ...
PA28 Activator beta Subunit/PSME2 ...
H00005721-R01
Species: Hu

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5721
Alternate Names
  • PA28B
  • PA28b
  • 11S regulator complex beta subunit
  • proteasome activator hPA28 subunit beta
  • REG-beta
  • proteasome activator complex subunit 2
  • 11S regulator complex subunit beta
  • proteasome activator 28-beta
  • Proteasome activator 28 subunit beta
  • MCP activator, 31-kD subunit
  • Activator of multicatalytic protease subunit 2
  • PA28betacell migration-inducing protein 22
  • REGbeta
  • proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

Research Areas for PA28 Activator beta Subunit/PSME2

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Ubiquitin Proteasome Pathway

PTMs for PA28 Activator beta Subunit/PSME2

Learn more about PTMs related to PA28 Activator beta Subunit/PSME2.

Phosphorylation
Ubiquitination
Cleavage
Oxidation

Bioinformatics Tool for PA28 Activator beta Subunit/PSME2

Discover related pathways, diseases and genes to PA28 Activator beta Subunit/PSME2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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