Species: Hu, Mu, Rt, Pm, Ch, Pm, Ma-Op, RM
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
55593 |
| Alternate Names |
- Deubiquitinating enzyme A
- DKFZp761A052
- DUBAdeubiquinating enzyme A
- EC 3.4.19.12
- MGC104871
- OTU domain containing 5
- OTU domain-containing protein 5
|
