OMA1 Products

Antibodies
OMA1 Antibody
OMA1 Antibody
NBP2-30971
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
OMA1 Antibody
OMA1 Antibody
NBP1-56970
Species: Hu, Fi
Applications: WB
Host: Rabbit Polyclonal
Proteins
Recombinant Human OMA1 Protei ...
Recombinant Human OMA1 Protein
H00115209-P01
Species: Hu
Applications: WB, ELISA, PA
OMA1 Recombinant Protein Anti ...
OMA1 Recombinant Protein Antigen
NBP2-30971PEP
Species: Hu
Applications: AC

Description

OMA1, also known as Metalloendopeptidase OMA1, mitochondrial, has 2 isoforms, a 524 amino acid long isoform that is 60 kDa and a short 486 amino acid isoform that is 56 kDa; widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver; participates in the quality control system in the inner membrane of mitochondria following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Studies are being performed on the relationship of this protein to amyotrophic lateral sclerosis, lateral sclerosis, childhood medulloblastoma, and medulloblastoma. OMA1 protein involvement has been observed with relation to diet induced thermogenesis, glucose metabolic process, misfolded or incompletely synthesized protein catabolic process, lipid metabolic process, negative regulation of mitochondrial fusion, and cristae formation processes.

Bioinformatics

Uniprot Human
Human
Product By Gene ID 115209
Alternate Names
  • MPRP1
  • 2010001O09Rik
  • EC 3.4.24.-
  • Metalloprotease-related protein 1
  • overlapping activity with M-AAA protease
  • ZMPOMA1
  • metalloprotease related protein 1
  • YKR087C
  • MPRP-1mitochondrial
  • DAB1
  • OMA1 homolog, zinc metallopeptidase (S. cerevisiae)

Pathways for OMA1

View related products by pathway and learn more about each of the pathways below.

Proteolysis
Mitochondrial Fusion
Translation
Membrane Fusion
Pathogenesis

PTMs for OMA1

Learn more about PTMs related to OMA1.

Cleavage

Bioinformatics Tool for OMA1

Discover related pathways, diseases and genes to OMA1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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