NUP214 Products

Description

Calcineurin is a widely distributed Ser/Thr, calcium and calmodulin-dependent protein phosphatase. It mediates the immunosuppressive actions of drugs such as FK506 and cyclosporin, and has also been implicated in a number of calcium-sensitive pathways in the nervous system. Calcineurin has been found to be associated with other proteins, such as calmodulin, FKBP12, the ryanodine receptor, inositol 1,4,5-trisphosphate, and a recently identified protein, calcineurin inhibitor (CAIN). CAIN has been shown to bind calcineurin through its C-terminal tail. Recent studies have shown CAIN to bind to both amphiphysin 1 and calcineurin simultaneously and therefore acts as a physiological inhibitor of calcineurin. The binding of CAIN to amphiphysin 1 does not affect the interaction of amphiphysin 1 with other endocytic proteins. CAIN, like calcineurin, is highly expressed in neurons and other tissues.

Bioinformatics

Entrez	8021 Human 296634 Rat
Product By Gene ID	8021
Alternate Names	214 kDa nucleoporin CAINputative oncogene D9S46Enuclear pore complex protein Nup214 KIAA0023 MGC104525 N214 nucleoporin 214kD (CAIN) nucleoporin 214kDa Nucleoporin Nup214 p250 Protein CAN

Research Areas for NUP214

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Angiogenesis