NTH1 Products

Antibodies
NTH1 Antibody
NTH1 Antibody
NB100-302
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
NTH1 Antibody (208521)
NTH1 Antibody (208521)
MAB2675
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Proteins
NTH1 Recombinant Protein
NTH1 Recombinant Protein
NBP1-72459
Species: Hu
Applications: PAGE
RNAi
NTH1 RNAi
NTH1 RNAi
H00004913-R01
Species: Hu

Description

Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 4913
Alternate Names
  • EC 4.2.99.18
  • endonuclease III-like protein 1
  • OCTS3NTH1nth (E.coli endonuclease III)-like 1
  • nth endonuclease III-like 1 (E. coli)

Research Areas for NTH1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

PTMs for NTH1

Learn more about PTMs related to NTH1.

Oxidation
Cleavage
Reduction

Bioinformatics Tool for NTH1

Discover related pathways, diseases and genes to NTH1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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