Hu, Mu, Rt, BvApplications:
WB, ICC/IF, IHC, IHC-PHost:
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
|Product By Gene ID
- EC 18.104.22.168
- endonuclease III-like protein 1
- OCTS3NTH1nth (E.coli endonuclease III)-like 1
- nth endonuclease III-like 1 (E. coli)
Bioinformatics Tool for NTH1
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