NTH1 Products

Description

Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites. A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.

Bioinformatics

Uniprot	AAH03014.1 Human NP_002519 Human P78549 Human
Product By Gene ID	4913
Alternate Names	EC 4.2.99.18 endonuclease III-like protein 1 nth endonuclease III-like 1 (E. coli) OCTS3NTH1nth (E.coli endonuclease III)-like 1

Research Areas for NTH1

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Cancer
Chromatin Research
Core ESC-Like Genes
DNA Repair
Stem Cell Markers