Nrf2 Products

Antibodies
Nrf2 Antibody
Nrf2 Antibody
Species: Hu, Mu, Rt, Al, Av, Pl, Ze, RM
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP, KD
Host: Rabbit Polyclonal
Nrf2 Antibody (383727) [Uncon ...
Nrf2 Antibody (383727) [Unconjugated]
MAB3925
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Nrf2 [p Ser40] Antibody (SU03 ...
Nrf2 [p Ser40] Antibody (SU0334)
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
ELISA Kits
Human Nrf2 ELISA Kit (Colorim ...
Human Nrf2 ELISA Kit (Colorimetric)
NBP3-08160
Species: Hu
Applications: ELISA
Mouse Nrf2 ELISA Kit (Colorim ...
Mouse Nrf2 ELISA Kit (Colorimetric)
NBP2-76758
Species: Mu
Applications: ELISA
Rat Nrf2 ELISA Kit (Colorimet ...
Rat Nrf2 ELISA Kit (Colorimetric)
NBP3-08161
Species: Rt
Applications: ELISA
Proteins
Recombinant Human Nrf2 GST (N ...
Recombinant Human Nrf2 GST (N-Term...
H00004780-P01
Species: Hu
Applications: WB, ELISA, Func, PA, AP, KA
Recombinant Human Nrf2 His Pr ...
Recombinant Human Nrf2 His Protein
NBP2-51955
Species: Hu
Applications: PAGE
Nrf2 Recombinant Protein Anti ...
Nrf2 Recombinant Protein Antigen
NBP2-58702PEP
Species: Hu
Applications: AC

Description

Nrf2 is a transcription factor which belongs to the Cap N Collar (CNC-bZIP) subfamily with an implication in adaptive responses to oxidative stress. Nrf2 is a basic leucine zipper transcription factor that can bind to a NF-E2/AP-1 repeat sequence in the promoter of the beta-globin gene and has two types of binding partners, a cytoplasmic repressor (Keap I) and multiple nuclear binding partners. During oxidative stress on a cell, Nrf2 is released from Keap I, possibly via PKC phosphorylation at serine 40, and translocates to the nucleus. In the nucleus, Nrf2 binds to antioxidant responsive element (ARE) and leads to transcriptional activation of downstream genes for GSTs, glutamate-cysteine ligase, HO-1, and thioredoxin. Nrf2 and its downstream proteins have shown to have important functions in protection against oxidative stress or chemical-induced cellular damage in liver and lung, prevention in cancer formation in GI tract, and promotion of the wound-healing process.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 4780
Alternate Names
  • HEBP1
  • NF-E2-related factor 2
  • NFE2-related factor 2
  • NRF2 erythroid derived 2, like 2
  • nuclear factor (erythroid-derived 2)-like 2
  • nuclear factor erythroid 2-related factor 2
  • nuclear factor erythroid-derived 2-like 2

Research Areas for Nrf2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific

Bioinformatics Tool for Nrf2

Discover related pathways, diseases and genes to Nrf2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Nrf2 Blog Posts

Check out the latest blog posts on Nrf2.
Exploring the Many Roles of PGC-1 alpha
The peroxisome proliferator-activated receptor gamma, co-activator 1 (PGC-1 alpha or PPARGC1A) gene encodes a 91 kDa nuclear protein that acts as a transcriptional co-activator involved in energy metabolism. Interaction with PPAR gamma allows it to in...    Read more.
PGC-1 alpha: Roles in Mitochondrial Biogenesis and Disease
An important aspect of mitochondria maintenance includes biogenesis to replenish damaged and degraded mitochondrial structures. The regulation of mitochondrial biogenesis is very complex and numerous genes regulate and synchronize protein synthesis fr...    Read more.
Crosstalk Between Oxidative Stress and Autophagy
By Christina Towers, PhD. Role of Reactive Species in Cellular FunctionOxidative stress is a byproduct of an imbalance between oxidants and antioxidants present in the cell, resulting in dysfunctional redox si...    Read more.
Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease
 By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.
Autophagic flux: Is p62 a good indicator?
By Christina Towers, PhD Is p62 a good indicator of autophagic flux? The short answer: Yes … but … SQSTM1 encodes the cargo adaptor protein, p62, which interacts with autophagic substrates and delivers them to aut...    Read more.
Understanding ‘Y’ in Breast Cancer: Crucial Role of DNA/RNA-binding Protein YB-1 in the Development, Pre-Invasive, and Metastatic Phases
Jamshed Arslan, Pharm D, PhD In the United States, 1 in 8 women will be diagnosed with breast cancer in her lifetime.1 Despite the prevalence, cancer genesis is a mystery. The heterogeneity of cancers makes it diff...    Read more.
Read more Nrf2 related blogs.