Hu, Mu, Rt, MkApplications:
WB, ChIP, ICC/IF, IHC, IHC-P, IPHost:
Hu, Mu, RtApplications:
WB, ELISA, ICC/IFHost:
WB, ELISA, PA
Applications: WB, ELISA, PA
Applications: RNAi, RNAi SP
Nrf2 is a transcription factor which belongs to the Cap N Collar (CNC-bZIP) subfamily with an implication in adaptive responses to oxidative stress. Nrf2 is a basic leucine zipper transcription factor that can bind to a NF-E2/AP-1 repeat sequence in the promoter of the beta-globin gene and has two types of binding partners, a cytoplasmic repressor (Keap I) and multiple nuclear binding partners. During oxidative stress on a cell, Nrf2 is released from Keap I, possibly via PKC phosphorylation at serine 40, and translocates to the nucleus. In the nucleus, Nrf2 binds to antioxidant responsive element (ARE) and leads to transcriptional activation of downstream genes for GSTs, glutamate-cysteine ligase, HO-1, and thioredoxin. Nrf2 and its downstream proteins have shown to have important functions in protection against oxidative stress or chemical-induced cellular damage in liver and lung, prevention in cancer formation in GI tract, and promotion of the wound-healing process.
Research Areas for Nrf2
Find related products by research area and learn more about each of the different research areas below.Phospho-Specific
Bioinformatics Tool for Nrf2
Discover related pathways, diseases and genes to Nrf2. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related Nrf2 Blog Posts
Check out the latest blog posts on Nrf2.
Read more Nrf2 related blogs.
|PGC-1 alpha: Roles in Mitochondrial Biogenesis and Disease
An important aspect of mitochondria maintenance includes biogenesis to replenish damaged and degraded mitochondrial structures. The regulation of mitochondrial biogenesis is very complex and numerous genes regulate and synchronize protein synthesis fr... Read more.
|Exploring the Many Roles of PGC-1 alpha
The peroxisome proliferator-activated receptor gamma, co-activator 1 (PGC-1 alpha or PPARGC1A) gene encodes a 91 kDa nuclear protein that acts as a transcriptional co-activator involved in energy metabolism. Interaction with PPAR gamma allows it to in... Read more.