Nrf2 Products

Antibodies
Nrf2 Antibody (383727)
Nrf2 Antibody (383727)
MAB3925
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
Nrf2 Antibody
Nrf2 Antibody
NBP1-82530
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Nrf2 Antibody (2G7)
Nrf2 Antibody (2G7)
H00004780-M02
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Proteins
Recombinant Human Nrf2 Protei ...
Recombinant Human Nrf2 Protein
H00004780-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Nrf2 Protei ...
Recombinant Human Nrf2 Protein
H00004780-Q01
Species: Hu
Applications: WB, ELISA, PA
Nrf2 Recombinant Protein Anti ...
Nrf2 Recombinant Protein Antigen
NBP1-82530PEP
Species: Hu
Applications: AC
RNAi
Nrf2 RNAi
Nrf2 RNAi
H00004780-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Nrf2 is a transcription factor which belongs to the Cap N Collar (CNC-bZIP) subfamily with an implication in adaptive responses to oxidative stress. Nrf2 is a basic leucine zipper transcription factor that can bind to a NF-E2/AP-1 repeat sequence in the promoter of the beta-globin gene and has two types of binding partners, a cytoplasmic repressor (Keap I) and multiple nuclear binding partners. During oxidative stress on a cell, Nrf2 is released from Keap I, possibly via PKC phosphorylation at serine 40, and translocates to the nucleus. In the nucleus, Nrf2 binds to antioxidant responsive element (ARE) and leads to transcriptional activation of downstream genes for GSTs, glutamate-cysteine ligase, HO-1, and thioredoxin. Nrf2 and its downstream proteins have shown to have important functions in protection against oxidative stress or chemical-induced cellular damage in liver and lung, prevention in cancer formation in GI tract, and promotion of the wound-healing process.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 4780
Alternate Names
  • NRF2 erythroid derived 2, like 2
  • nuclear factor erythroid-derived 2-like 2
  • NF-E2-related factor 2
  • nuclear factor erythroid 2-related factor 2
  • HEBP1
  • NFE2-related factor 2
  • nuclear factor (erythroid-derived 2)-like 2

Research Areas for Nrf2

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific

Bioinformatics Tool for Nrf2

Discover related pathways, diseases and genes to Nrf2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Nrf2 Blog Posts

Check out the latest blog posts on Nrf2.
PGC-1 alpha: Roles in Mitochondrial Biogenesis and Disease
An important aspect of mitochondria maintenance includes biogenesis to replenish damaged and degraded mitochondrial structures. The regulation of mitochondrial biogenesis is very complex and numerous genes regulate and synchronize protein synthesis fr...    Read more.
Exploring the Many Roles of PGC-1 alpha
The peroxisome proliferator-activated receptor gamma, co-activator 1 (PGC-1 alpha or PPARGC1A) gene encodes a 91 kDa nuclear protein that acts as a transcriptional co-activator involved in energy metabolism. Interaction with PPAR gamma allows it to in...    Read more.
Read more Nrf2 related blogs.