NRAS Products

Description

Ras (p21), a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30% of all human cancer (4).

Bioinformatics

Product By Gene ID	4893
Alternate Names	ALPS4 GTPase NRas HRAS1 neuroblastoma RAS viral (v-ras) oncogene homolog N-ras protein part 4 N-ras NRAS1 NS6 Transforming protein N-Ras v-ras neuroblastoma RAS viral oncogene homolog

Research Areas for NRAS

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cell Cycle and Replication
mTOR Pathway

Related NRAS Blog Posts

Check out the latest blog posts on NRAS.

Autophagy and RAS signaling: Clinical implications By Christina Towers, PhD The cellular recycling process known as autophagy is currently being targeted in over 60 clinical trials focused on treating different types of cancer1. To date, the only autophagy-targeted ...    Read more.

Read more NRAS related blogs.