Notch-3 Products

Description

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Bioinformatics

Entrez	4854 Human
Uniprot	NP_000426 Human
Product By Gene ID	4854
Alternate Names	CADASIL CASILneurogenic locus notch homolog protein 3 Notch (Drosophila) homolog 3 notch 3Notch homolog 3 (Drosophila) Notch homolog 3 Notch3 Notch-3

Research Areas for Notch-3

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Cancer