NIK/MAP3K14 Products

Description

NIK (NF kappa B inducing kinase), also called MAP3K14, is a widely expressed 947 amino acid (aa), ~100 kDa cytoplasmic protein of the MAP kinase family. NIK participates in a non-canonical NFkB signaling cascade in which its activity and expression are elevated by TNF and related ligands. NIK activates IKKa/b, which releases NFkB subunits for translocation to the nucleus. Within the region used as an immunogen, human NIK shares 94% and 95% aa sequence identity with mouse and rat NIK, respectively.

Bioinformatics

Uniprot	Q99558
Product By Gene ID	9020
Alternate Names	EC 2.7.11.25 FTDCR1B HS HSNIK HSNIKserine/threonine protein-kinase MAP3K14 mitogen-activated protein kinase kinase kinase 14 NIK NIKNF-kappa-beta-inducing kinase Serine/threonine-protein kinase NIK