Nicastrin Products

Description

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq]

Bioinformatics

Product By Gene ID	23385
Alternate Names	anterior pharynx-defective 2 APH2 ATAG1874 KIAA0253APH2 NCSTN Nicastrin

Research Areas for Nicastrin

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuronal Cell Markers
Neuroscience
Signal Transduction