Nicastrin Products

Antibodies
Nicastrin Antibody
Nicastrin Antibody
AF5378
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Nicastrin Antibody
Nicastrin Antibody
NBP1-77269
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Nicastrin Antibody
Nicastrin Antibody
NBP1-77270
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
Nicastrin Overexpression Lysa ...
Nicastrin Overexpression Lysate (D...
H00023385-T01
Species: Hu
Applications: WB
Nicastrin Overexpression Lysa ...
Nicastrin Overexpression Lysate (N...
NBP2-10287
Applications: WB
Proteins
Nicastrin Partial Recombinant ...
Nicastrin Partial Recombinant Protein
H00023385-Q01
Species: Hu
Applications: WB, ELISA, PA
Nicastrin Recombinant Protein ...
Nicastrin Recombinant Protein
H00023385-P01
Species: Hu
Applications: WB, ELISA, PA
Nicastrin Recombinant Protein ...
Nicastrin Recombinant Protein Antigen
NBP2-38741PEP
Species: Hu
Applications: AC
RNAi
Nicastrin RNAi
Nicastrin RNAi
H00023385-R01
Species: Hu

Description

Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 23385
Alternate Names
  • anterior pharynx-defective 2
  • ATAG1874
  • KIAA0253APH2
  • nicastrin

Pathways for Nicastrin

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Transport
Cognition
Histone H3 Acetylation
Viral Latency
Dna Recombination
Nuclear Export
Secretion
Chromatin Remodeling

Research Areas for Nicastrin

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuronal Cell Markers
Neuroscience
Signal Transduction

PTMs for Nicastrin

Learn more about PTMs related to Nicastrin.

Cleavage
Gamma-cleavage
Phosphorylation
Acetylation

Bioinformatics Tool for Nicastrin

Discover related pathways, diseases and genes to Nicastrin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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