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Nicastrin Products

Antibodies
Nicastrin Antibody (716918)
Nicastrin Antibody (716918)
MAB5378
NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips." class="big_lightbox" target="_blank"> Immunocytochemistry Nicastrin Antibody (716918)
Species: Hu
Applications: ICC/IF
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 FAB5378U-100UG
Alexa Fluor 405 FAB5378V-100UG
Alexa Fluor 488 FAB5378G-100UG
Alexa Fluor 532 FAB5378X-100UG
Alexa Fluor 594 FAB5378T-100UG
Alexa Fluor 647 FAB5378R-100UG
Alexa Fluor 700 FAB5378N-100UG
Alexa Fluor 750 FAB5378S-100UG
Alexa Fluor Plus 405 FAB5378AFP405-100UG
Alexa Fluor Plus 488 FAB5378AFP488-100UG
Alexa Fluor Plus 555 FAB5378AFP555-100UG
Alexa Fluor Plus 594 FAB5378AFP594-100UG
Alexa Fluor Plus 647 FAB5378AFP647-100UG
Alexa Fluor Plus 680 FAB5378AFP680-100UG
Formulation Catalog # Availability Price  
Carrier Free MAB5378-SP
Nicastrin Antibody - BSA Free ...
Nicastrin Antibody - BSA Free
NBP1-77269
Western Blot Nicastrin Antibody - BSA Free
Immunocytochemistry/ Immunofluorescence Nicastrin Antibody - BSA Free
Immunohistochemistry-Paraffin Nicastrin Antibody - BSA Free
Immunocytochemistry/ Immunofluorescence Nicastrin Antibody - BSA Free
Immunocytochemistry/ Immunofluorescence Nicastrin Antibody - BSA Free
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 NBP1-77269AF350
Alexa Fluor 405 NBP1-77269AF405
Alexa Fluor 488 NBP1-77269AF488
Alexa Fluor 532 NBP1-77269AF532
Alexa Fluor 594 NBP1-77269AF594
Alexa Fluor 647 NBP1-77269AF647
Alexa Fluor 700 NBP1-77269AF700
Alexa Fluor 750 NBP1-77269AF750
Alexa Fluor Plus 405 NBP1-77269AFP405
Alexa Fluor Plus 488 NBP1-77269AFP488
Alexa Fluor Plus 555 NBP1-77269AFP555
Alexa Fluor Plus 594 NBP1-77269AFP594
Alexa Fluor Plus 647 NBP1-77269AFP647
Alexa Fluor Plus 680 NBP1-77269AFP680
Allophycocyanin NBP1-77269APC
Biotin NBP1-77269B
CoraFluor 1 NBP1-77269CL1
DyLight 350 NBP1-77269UV
DyLight 405 NBP1-77269V
DyLight 488 NBP1-77269G
DyLight 550 NBP1-77269R
DyLight 594 NBP1-77269DL594
DyLight 650 NBP1-77269C
DyLight 680 NBP1-77269FR
DyLight 755 NBP1-77269IR
FITC NBP1-77269F
HRP NBP1-77269H
Janelia Fluor 525 NBP1-77269JF525
Janelia Fluor 549 NBP1-77269JF549
Janelia Fluor 646 NBP1-77269JF646
Janelia Fluor 669 NBP1-77269JF669
PE NBP1-77269PE
PerCP NBP1-77269PCP
mFluor Violet 450 SE NBP1-77269MFV450
mFluor Violet 500 SE NBP1-77269MFV500
mFluor Violet 610 SE NBP1-77269MFV610
Formulation Catalog # Availability Price  
BSA Free NBP1-77269-0.025mg
Nicastrin Antibody (716910)
Nicastrin Antibody (716910)
MAB53781
HAF007). Specific bands were detected for Nicastrin at approximately 110-120 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank"> Western Blot Nicastrin Antibody (716910)
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Alexa Fluor 350 FAB53781U-100UG
Alexa Fluor 405 FAB53781V-100UG
Alexa Fluor 488 FAB53781G-100UG
Alexa Fluor 532 FAB53781X-100UG
Alexa Fluor 594 FAB53781T-100UG
Alexa Fluor 647 FAB53781R-100UG
Alexa Fluor 700 FAB53781N-100UG
Alexa Fluor 750 FAB53781S-100UG
Alexa Fluor Plus 405 FAB53781AFP405-100UG
Alexa Fluor Plus 488 FAB53781AFP488-100UG
Alexa Fluor Plus 555 FAB53781AFP555-100UG
Alexa Fluor Plus 594 FAB53781AFP594-100UG
Alexa Fluor Plus 647 FAB53781AFP647-100UG
Alexa Fluor Plus 680 FAB53781AFP680-100UG
Formulation Catalog # Availability Price  
Carrier Free MAB53781-SP
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We have 17 Nicastrin Antibodies
Lysates
Nicastrin Overexpression Lysa ...
Nicastrin Overexpression Lysate
NBP2-10287
Western Blot Nicastrin Overexpression Lysate
Species: Hu
Applications: WB
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We have 1 Nicastrin Lysate
Proteins
Recombinant Human Nicastrin G ...
Recombinant Human Nicastrin GST (N...
H00023385-P01
Other Recombinant Human Nicastrin GST (N-Term) Protein
Species: Hu
Applications: WB, ELISA, Endotoxin, AP
Nicastrin Recombinant Protein ...
Nicastrin Recombinant Protein Antigen
NBP2-38741PEP
Species: Hu
Applications: AC
Nicastrin Recombinant Protein ...
Nicastrin Recombinant Protein Antigen
NBP2-57365PEP
Species: Hu
Applications: AC
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We have 5 Nicastrin Proteins

Description

Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. Nicastrin protein is physically associated with presenilin and plays an important role in stabilization and correct localization of presenilin to the membrane-bound gamma-secretase complex. Nicastrin also serves as a docking site for gamma-secretase substrates such as APP and Notch, directly binding to them and presenting them properly to gamma-secretase to ensure the correct cleavage process.

Bioinformatics

Uniprot
AAH47621
Human
AAH47621.1
Human
NICA_HUMAN
Human
NP_056146
Human
Q92542
Human
Product By Gene ID 23385
Alternate Names
  • anterior pharynx-defective 2
  • ATAG1874
  • KIAA0253APH2
  • nicastrin

Research Areas for Nicastrin

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuronal Cell Markers
Neuroscience
Signal Transduction