Neurophysin II/Arg-vasopressin Products

Description

Vasopressin, also known as arginine vasopressin (AVP), or antidiuretic hormone (ADH), is a posterior pituitary hormone that is synthesised in the hypothalamus. Vasopressin is synthesised as a precursor protein that consists of arginine vasopressin and two associated proteins, neurophysin 2 and the glycopeptide copeptin. Vasopressin, together with its carrier protein neurophysin II, is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney and also causes vasoconstriction of the peripheral vessels. Vasopressin can also contract smooth muscle during parturition and lactation. It also plays a role in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in the vasopressin precursor cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is characterised by persistant thirst, polydipsia and polyuria.

Bioinformatics

Entrez	11998 Mouse 24221 Rat 280728 Bovine 551 Human
Uniprot	NP_000481 Human P01180 Bovine
Product By Gene ID	551
Alternate Names	arginine vasopressin ARVP AVP-NPII AVRP neurohypophyseal vasopressin-neurophysin 2-copeptin VP

Research Areas for Neurophysin II/Arg-vasopressin

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Cell Biology
Lipid and Metabolism