NETO1 Products

Description

Neuropilin and tolloid-like protein 1 (NETO1), also known as Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1 (BTCL1), is a type I transmembrane protein that is expressed in the brain and retina (1). The 511 amino acid (aa) residue mature human NETO1 contains a 322 aa extracellular domain (ECD) with two CUB domains and one class A LDL-receptor segment, a 21 aa transmembrane domain, and a 168 aa cytosol domain (1). Three human NETO1 splice isoforms exist, including a secreted soluble variant that shows an Asp-to-Glu transition at residue 157 followed by a premature truncation (1). The ECD of human NETO1 shares 97% and 98% aa identity with that of mouse and canine NETO1, respectively. NETO1 is expressed in the human brain and retina (1, 2). It increases the rate of GluK1 receptor desensitization and is a candidate NMDAR auxiliary subunit regulating channel activities and synaptic transmission (3, 4). NETO1 expression is associated with metastasis and poor survival in epithelial ovarian cancer (5).

Bioinformatics

Uniprot	Q8TDF5.1
Product By Gene ID	81832
Alternate Names	BCTL1 Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor classA domains protein 1 BTCL1 BTCL1BCTL1neuropilin and tolloid-like protein 1 FLJ41325 NETO1 neuropilin (NRP) and tolloid (TLL)-like 1