Ndufs1 Products

Description

Ndufs1 is encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. [provided by RefSeq]

Bioinformatics

Uniprot	AAH30833 Human NM_005006 Human NP_004997.4 Human O95299 Human P28331 Human
Product By Gene ID	4719
Alternate Names	CI-75k CI-75kD CI-75Kd complex I 75kDa subunit complex I, mitochondrial respiratory chain, 75-kD subunit Complex I-75kD EC 1.6.5.3 EC 1.6.99.3 MGC26839 mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coenzyme Qreductase) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Qreductase) NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial PRO1304

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