NDUFA9 Products

Description

ATP is generated via oxidative phosphorylation (Oxphos) in the mitochondria of almost all cells. The protein components of Oxphos, 4 respiratory chain complexes (I-IV) and an ATP synthase, are encoded in both the mitochondrial and nuclear genomes. Of the 4 respiratory chain complexes, complex I is the largest at 900 kD and contains at least 41 polypeptide subunits, 7 of which are encoded in the mitochondria, the remaining subunits are encoded in the nucleus. The multisubunit NADH:ubiquinone oxidoreductase is the first enzyme complex. By use of chaotropic agents, complex I can be fragmented into 3 different fractions. The flavoprotein fraction contains the NDUFV1, NDUFV2, and NDUFV3 subunits. The iron-sulfur protein (IP) fraction contains at least 7 subunits, NDUFS1-NDUFS6 and NDUFA5. The remaining subunits are part of the hydrophobic protein (HP) fraction. NDUFA9 is part of the hydrophobic protein fraction of the enzyme complex. However, it is predominantly hydrophilic, and appears to lie mostly outside the lipid bilayer.

Bioinformatics

Uniprot	NP_004993 Human NP_004993.1 Human NM_005002 Human Q16795 Human
Product By Gene ID	4704
Alternate Names	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (39kD) short chain dehydrogenase/reductase family 22E, member 1 NADH-ubiquinone oxidoreductase 39 kDa subunit NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFS2L NADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase) CI-39kD complex I 39kDa subunit Complex I-39kD MGC111043 SDR22E1 CI39k CI-39k CC6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

Diseases related to NDUFA9

Discover more about diseases related to NDUFA9.

Malignant Neoplasms
Carcinoma
Neoplasms
Leigh Disease
Diabetes Mellitus
Nicotinamide Adenine Dinucleotide Coenzyme Q Reductase Deficiency
Myocardial Ischemia
Reperfusion Injury
Embryonal Carcinoma
Mitochondrial Diseases
De Novo Mutation
Neoplasm Invasiveness
Hypokinesia
Endoplasmic Reticulum Stress
Insulin Resistance
Hyperglycemia
Cytogenetic Abnormality
Dysequilibrium Syndrome
Malignant Neoplasm Of Prostate

Pathways for NDUFA9

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Aging
Oxidative Phosphorylation
Translation
Cell Death
Protein Acetylation
Transport
Gene Silencing
Electron Transport
Insulin Secretion
Electron Transport Chain
Proteolysis
Glycosylation
Energy Homeostasis
Localization
Cell Cycle
Fatty Acid Oxidation
Secretion
Cell-cell Adhesion

Research Areas for NDUFA9

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Core ESC-Like Genes
Stem Cell Markers

PTMs for NDUFA9

Learn more about PTMs related to NDUFA9.

Acetylation
Phosphorylation
Oxidation

Bioinformatics Tool for NDUFA9

Discover related pathways, diseases and genes to NDUFA9. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.